John Adler and Trip Adler discuss their entrepreneurial experience and evolution as business leaders: John Adler describes his bumpy course in developing his biotechnology company, Accuray Incorporated; while his son Trip emphasizes the need for persistence and confidence in developing Scribd, a social publishing site. Despite building companies in different fields, the two offer the same central advice toward building a successful business: trust yourself, focus on developing a great product, and remember that there are no rules.