Young people with mammoth commercial success have bred a new kind of philanthropic entrepreneur, says Google.org’s Executive Director Larry Brilliant. And Brilliant also explains his optimism in smallpox, using it as a case study on a managed disease that once killed half a billion people worldwide. Through global unity and a concentrated effort, akin to what Google.org strives to accomplish in other areas, the virus was eradicated; thanks, in equal parts, to scientific discovery and philanthropic will.