A few companies into his entrepreneurial life, William Hagstrom, CEO of Crescendo Bioscience, has some advice for those who are just starting out. An entrepreneur must think about and understand risk better, so he can ultimately minimize it. He boils the many insights into some hard-learned lessons: architect the business more deeply and muscle it with talent, so the programs are stouter and the company makes a bigger impact. And while it may seem obvious, he says that a CEO must build in time to think and reflect about what’s going on in the business.